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Interest and other income, net and interest expense three months ended june 30, six months ended june 30, in thousands ; 2005 2004 % change 2005 2004 % change interest and other income, net $ 1, 873 $ 2, 583 27 ; % $ 4, 808 $ 4, 867 1 ; % interest expense 2, 709 ; 1, 351 ; 100 % 4, 851 ; 2, 736 ; 77 % interest and other income and expense interest income for the three and six months ended june 30, 2005 decreased from the comparable periods in 2004 due to the reduced interest earned on our cash, cash equivalents and marketable securities balances primarily as a result of lower interest rates and lower invested balances.
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Antares Pharma Inc. revenues are realized, we project Antares may need to raise additional cash to finance its operations sometime in 2008. Should the TEVA project be delayed, or payment issues arise from its partners, we project Antares will need to raise cash around 4Q 2007 or early 2008.
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Moisturizers are used to restore and or to maintain a normal function of the stratum corneum SC ; . Mostly they are used on the indication of so-called dry skin. When performing product testing of moisturizers, bioengineering devices are used for evaluating how these products affect the function of SC, the main diffusion barrier in the skin. Biophysical measurements of dry skin need to be carefully evaluated. A number of highly developed noninvasive methods for the study of skin physiology have appeared during recent years and a number of papers on the use of these methods are now being published. D. Van Neste, Skin Hydration in Detergent-Induced Irritant Dermatitis, Bioengineering of the Skin: Water and the Stratum Corneum, 223-232, 1994 It is a thermodynamic rule that water escapes "passively" through the body surface of a homeothermic living organism and returns into a cool and dry environment. There is a consensus in viewing the primary role of the epidermis as a producer of a structurally highly ordered hydrophobic domain usually confined to the extracellular spaces within the stratum corneum SC ; . Indeed, after terminal differentiation, corneocytes are embedded in a continuous meshwork of lipid bilayers. The aim of the specialized domain is to prevent desiccation of the body. In this concept, programmed cell death of SC cells makes them like missiles with a lipid load synthesized in the cell after launching and extruding from the cell after completion of the differentiation program. Recently it became clear that flux of water through the SC is a regulatory mechanism for cell proliferation. P. Clarys, C. Eeckhout, J. Taeymans, P. Gross, A.O. Barel, Influence of short daily exposure to thermal water on the hydration state of the skin, Threat to the Skin, 333-337, 1994 The thermal Kurzentrum of Lenk Switzerland ; is one of the spas recognized by the Department of Health of Switzerland as a centre specialized in the treatment of rheumatic patients. Part of the typical 3-week cure in the centre consist of daily bathing in hot thermal water containing high concentrations of salts and sulphur sulphates and hydrogen sulphide ; . According to recent data from balneotherapeutic treatments, the sulphur which penetrates the skin is oxidized and provokes various physiological responses in the skin: vasodilatation in the microcirculation, an analgesic influence on the pain receptors and inhibition of the immune response. J.D. Bscher, B.C. Lippold, Messung feuchthaltender Effekte an menschlicher Haut, Krankenhauspharmazie, 15. Jahrgang, Nr. 12, 1994 Die Wirkung von Feuchthaltern auf die Barriere Stratum corneum wird mit einem Corneometer bestimmt. Diese nicht invasive und einfache Methode erlaubt quantitativ, die Vernderung der Hornschichthydratation zu messen. Glycerol, Natriumthioglycolat, Natriumlactat, Harnstoff, Propylenglycol und Natriumedetat erhhen significant 7-12% ; , Diethylenglycolmonoethylether Transcutol ; erniedrigt schwach in 10%-iger Lsung die Hautfeuchte, 2-Butanol und Ethanol bleiben praktisch ohne Einflu. Dr. H.P. Nissen, Comparative Studies of Skin Roughness Measurements by Profilometry and a New Image Analysis System, Cosmetic and Toiletries Manufacture World-wide, Jan. 95 The characterisation of the effects of skin care products on the topography of the horny layer is a valuable component in the substantiation of treatment products' efficacy. Skin roughness is a very important parameter in the characterization of cosmetic skin properties. Smooth, supple skin is a perceptible effect that can be achieved by means of cosmetic skin care products. Up to now, however, it has been difficult to record the roughens of the skin and to define it satisfactorily by measuring technique. In this study a new method for computer assisted structural analysis of the skin surface is presented, which uses a special image analysis technique. This new method is compared with the profilometry and the conventional image analyser technique. I. Diepenbrock, U. Heinrich, H. Tronnier, Der Einflu von Nikotin auf die Haut, Parfmerie und Kosmetik 12 95 Die Beschaffenheit der Haut als grtes menschliches Organ ist wie keine zweite ein Gradmesser fr das Alter des gesamten Organismus. Nicht selten lassen sich durch ihren Zustand Rckschlsse auf vorhandene Erkrankungen schlieen. Der Einflu des Rauchens nun auf die Hautelastizitt besttigt. Pamelor also plays a role in the storage, release and transport of catecholamine. 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